There are 8 disease interactions with Lamictal (lamotrigine) which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. 2010 Feb;32(2):338-46. doi: 10.1016/j.clinthera.2010.02.012. There is 1 alcohol/food/lifestyle interaction with Lamictal (lamotrigine). There may be other interactions with drugs that are not listed here. June 2019. HHS Vulnerability Disclosure, Help Usually avoid combinations; use it only under special circumstances. Available for Android and iOS devices. If one is taking lithium for bipolar disorder conditions, then they need to carefully monitor their salt intake because any sudden increase or decrease in the amount of sodium they consume can affect lithium levels. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. FOIA Liver diseaseUse with caution. The most common side effects noticed because of lamotrigine are blurred vision, double vision, clumsiness, unsteadiness, dizziness, or drowsiness. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. It should melt quickly. LAMICTAL Starter Kits and LAMICTAL ODT Patient Titration Kits are available for the first 5 weeks of treatment. You may need urgent medical care. Adults not taking valproic acid (Depakote) but taking carbamazepine (Tegretol), phenobarbital (Luminal), phenytoin (Dilantin), or primidone (Mysoline)At first, 50 mg of lamotrigine once a day for 2 weeks, then a total of 100 mg divided into 2 smaller doses each day for 2 weeks. If you're being sick, take small, frequent sips of water or squash to avoid dehydration. Its tincture is indicated as a diarrhea treatment. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Keep using all of your seizure medicines unless your doctor tells you to stop. If you're told by your doctor to take the medicine in a certain way, take it that way. After this, your doctor may gradually increase your dose as needed. 2013;170(11):1240-7. doi:10.1176/appi.ajp.2013.13010006. However, the dose is usually not more than 400 mg a day. 2016;36(6):554-61. doi:10.1097/JCP.0000000000000601. Adults and children older than 13 years of age taking valproic acid (Depakote)At first, 25 mg of lamotrigine once every other day for 2 weeks, then 25 mg once a day for 2 weeks. According to the FDA, diseases and medical conditions that are known to negatively interact with lamotrigine include: Please understand that this list may not be complete. It is important that your doctor check your or your child's progress at regular visits, especially during the first few months of your treatment with lamotrigine. This content does not have an Arabic version. DrugGenius225 S. Mermac AveUnit 832TClayton, MO 63131. Lamotrigine is usually taken 1 or 2 times daily with or without food. Lamotrigine is one such problem that can easily be cured if proper care and medication are taken under care. Standard tablets should be swallowed whole with a drink of water. Regarding breastfeeding, caution is advised since lamotrigine does pass into breast milk. After this, your doctor may gradually increase your dose as needed. Lamotrigine. . And the answer is absolutely yes, there are medicines that can make you cycle into a mood swing -- an episode of mania. If there are interactions, use is not recommended or the usage amount and timeframe will have to be adjusted in order to prevent or reduce the risk of negative interactions occurring from other drugs, medical conditions, or even food and drink. the unsubscribe link in the e-mail. In New Zealand, lamotrigine is available in different strength tablets (2 mg, 5 mg, 25 mg, 50 mg, 100 mg . Children not taking valproic acid (Depakote), carbamazepine (Tegretol), phenobarbital (Luminal), phenytoin (Dilantin), or primidone (Mysoline) At first, 0.3 mg/kg of body weight of lamotrigine given in one dose or two smaller doses each day for 2 weeks, then 0.6 mg/kg of body weight divided into 2 smaller doses each day for 2 weeks. Your doctor can best discuss the duration of treatment you need based on your symptoms and illness. Do not double doses. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. However, grapefruit and grapefruit juice may negatively interact with some bipolar medications. Please check with the appropriate physician regarding health questions and concerns. Some problems can just be overcome with the help of medicines prescribed by a certified doctor or timely care. However, the dose is usually not more than 250 mg a day. Adults taking valproic acid (Depakote)At first, 25 mg of lamotrigine once every other day for 2 weeks, then 25 mg once a day for 2 weeks. Tell your doctor right away if you have unusual changes in your menstrual cycle such as breakthrough bleeding while taking lamotrigine and birth control pills or other female hormonal products. What Are Lamotrigine's Potential Side Effects? Call your doctor for medical advice about side effects. official website and that any information you provide is encrypted Portions of this document last updated: Feb. 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/lamotrigine-oral-route/precautions/DRG-20067449. Investigation of formulation variables affecting the properties of lamotrigine nanosuspension using fractional factorial design. Lamotrigine is used alone or with other medications to treat epileptic seizures in adults and children. Ozempic - Foods To Avoid Sometimes the foods we eat and the beverages we drink can also interact with our medications. This information is being provided as a community outreach effort of the American Association of PsychiatricPharmacists. This information is for educational and informational purposes only and is not medical advice. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Do not double your dose or take more than what is prescribed. Well with this you know some foods to avoid when taking lamotrigine. Using both substances at the same time may impair your mental and motor function. After this, your doctor may gradually increase your dose as needed. Lamotrigine can be taken either with or without food. Do not stop taking lamotrigine without first checking with your doctor. Your mental health provider should justify his or her thinking in recommending an off-label treatment. Read and follow these instructions carefully. After this, your doctor may gradually increase your dose as needed. information highlighted below and resubmit the form. What vitamins affect lamotrigine? After this, your doctor may gradually increase your dose as needed. Bookshelf Though new data show the medication may increase the risk of arrhythmias . It is a safe and effective medication when used as directed. ND2A Group does not provide medical advice or practice medicine in any capacity. Plasma lamotrigine concentrations were determined and pharmacokinetic parameters studied. Inform MD Before taking lamotrigine, tell your doctor about all of your medical conditions, including if you: Dispersible tablets may be chewed, stirred into a small amount of water. Methylphenidate or Dexmethylphenidate (Concerta, Ritalin and others), What to Avoid with Psychiatric Medications, Weight Gain Related to Psychiatric Treatments, ECT, TMS and Other Brain Stimulation Therapies, American Association of Psychiatric Pharmacists, Creative Commons Attribution-NoDerivatives 4.0 International License, Oral disintegrating tablets: 25 mg, 50 mg, 100 mg, 200 mg, Extended-release tablets: 25 mg, 50 mg, 100 mg, 200 mg, 250 mg, 300 mg, Extended-release tablets: 25mg, 50 mg, 100 mg, 200 mg, 250 mg, 300 mg, Depressed mood feeling sad, empty, or tearful, Feeling worthless, guilty, hopeless, or helpless, Loss of interest or pleasure in normal activities, Sleep and eat more or less than usual (for most people it is less), Low energy, trouble concentrating, or thoughts of death (suicidal thinking), Psychomotor retardation (feeling like you are moving in slow motion), Feeling like your thoughts are too quick (racing thoughts), Getting involved in activities that are risky or could have bad consequences (e.g., excessive spending), Symptoms of your condition that bother you the most, If you have thoughts of suicide or harming yourself, Medications you have taken in the past for your condition, whether they were effective or caused any adverse effects. If you miss more than 3 days of medication, contact your prescriber because he/she may need to adjust your dose. The following medications may increase the level and effects of lamotrigine: The following medications may decrease the level and effect of lamotrigine: Lamotrigine may increase the level and effects of: It is very important to tell your doctor how you feel things are going during the first few weeks after you start taking lamotrigine. Lamotrigine has been approved and on the market for 24 years, and is available under the brand name Lamictal and as generics. Wait until the tablets are completely dispersed (about 1 minute), then swirl the solution and swallow it immediately. However, the dose is usually not more than 200 mg a day. However, the dose is usually not more than 100 mg a day. Eating grapefruit will increase Cymbalta's potential side effects since the drug will remain active in your system in higher concentrations . 10 Sometimes food can change how a . This medicine may cause hemophagocytic lymphohistiocytosis, a rare and life-threatening disorder wherein the body makes too many activated immune cells (macrophages and lymphocytes). It might help to take your lamotrigine after a meal or snack. The effects may be increased because of the slower removal of the medicine from the body. After this, your doctor may gradually increase your dose as needed. Follow your doctor's orders or the directions on the label. privacy practices. Ask your healthcare professional how you should dispose of any medicine you do not use. 2011 Jun;33(6):754-65. doi: 10.1016/j.clinthera.2011.05.046. Swallow the extended-release tablets whole. Dosage. Do not keep outdated medicine or medicine no longer needed. These thoughts or behaviors occurred in approximately 1 in 500 patients taking the antiepileptic class of medications. It will probably take several weeks to see big enough changes in your symptoms to decide if lamotrigine is the right medication for you. The condition is not good for a person getting treatment for lamotrigine. If you experience any thoughts or impulses to hurt yourself, you should contact your doctor immediately. \( 2.2 \) million B. Srichaiya A, Longchoopol C, Oo-Puthinan S, Sayasathid J, Sripalakit P, Viyoch J. Clin Ther. Stopping this medicine suddenly may cause your seizures to return or to occur more often. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If these reactions are especially bothersome, check with your doctor. Lamotrigine may cause blurred vision, double vision, clumsiness, unsteadiness, dizziness, or drowsiness. Patients with certain underlying cardiac disorders or heart rhythm problems may experience serious arrhythmias or life-threatening effects. Although some common Foods to avoid when taking Lamotrigine are as follows:-. Ginkgo is a traditional Chinese medicine also prescribed in the West by providers in the alternative health field 3. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Currently, other than slowing digestion, there are no known interactions between Ozempic and certain foods or beverages. Speak to a doctor if symptoms get worse or last longer than a week. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Latest news in the world of drugs, supplements & trending health. Side Effects. Clipboard, Search History, and several other advanced features are temporarily unavailable. After the tablet has melted, swallow or take a sip of water. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Joseph F Goldberg, MD responded: Dear An, No medicine is 100% guaranteed effective against relapse forever, so relapses can happen while taking Lamictal, as is the case for all medicines. Yet some . Moderately clinically significant. Opium derives from the plant known as opium poppy. Children not taking valproic acid (Depakote), carbamazepine (Tegretol), phenobarbital (Luminal), phenytoin (Dilantin), or primidone (Mysoline) At first, 0.3 mg/kg of body weight of lamotrigine given in one dose or two smaller doses each day for 2 weeks, then 0.6 mg/kg of body weight divided into 2 smaller doses each day for 2 weeks. This medicine should come with a Medication Guide. Copyright 2023 NAMI. The bioavailability of lamotrigine is affected by food, hence the present study was done to investigate the effect of two types of food on the bioavailability of lamotrigine. Different brands and dosage forms may not work the same way. To avoid an increased risk of rash, the recommended initial dose and subsequent dose escalations should not be exceeded. Lamotrigine may cause serious allergic reactions affecting multiple body organs (eg, liver or kidney). Lamotrigine is used alone or with other medications to prevent and control seizures. Interactions may occur when taking tramadol with lamotrigine. The amount of medicine that you take depends on the strength of the medicine. For oral dosage form (extended-release tablets): Adults and children older than 13 years of age not taking valproic acid (Depakote) but taking carbamazepine (Tegretol), phenobarbital (Luminal), phenytoin (Dilantin), or primidone (Mysoline)At first, 50 milligrams (mg) of lamotrigine once a day for 2 weeks, then 100 mg once a day for 2 weeks. For people with epilepsy, Lamictal prevents seizures . Helps in curing extreme mood swings, seizures, stress, anxiety, dizziness, or any other kind of mental problems faced by the patient. information and will only use or disclose that information as set forth in our notice of
We comply with the HONcode standard for trustworthy health information. Caffeine There is some debate about whether caffeine poses a moderate risk of adverse effects when taking methotrexate. Remove the tablet from the blister pack by peeling back the foil, then taking the tablet out. Lamotrigine falls under the class of anticonvulsants. Generic name: lamotrigine (la MOE tri jeen). Find out how you can be a NAMI HelpLine specialist. However, the dose is usually not more than 400 mg a day. However, the dose is usually not more than 600 mg a day. These foods and drinks may speed up the way your body metabolizes (breaks down) the epilepsy medication. In medicine, herbs are botanical remedies made of a plant's seeds, leaves, roots, bark, berries or blossoms. lamoTRIgine food Moderate Food Interaction Alcohol can increase the nervous system side effects of lamoTRIgine such as dizziness, drowsiness, and difficulty concentrating. Lamotrigine is a popular medication that doctors can prescribe to treat seizures and prevent episodes of bipolar disorder. Lamotrigine is a generic prescription drug primarily used to prevent certain types of seizures in people with epilepsy (including Lennox-Gastaut syndrome) as well as to help stabilize moods in people with bipolar I disorder. A randomized, open-label, three treatment, three period, single dose and cross-over study was done in nine healthy male volunteers. Do not push the tablet through the foil. Extended release tablets: Swallow whole. b. Lamotrigine's adverse effect profile is similar to placebo in all categories except sleep disruption. There are no reported drug interactions when taking gabapentin and lamotrigine, although side effects may be increased. Drug information provided by: IBM Micromedex. 2022 The American Association of Psychiatric Pharmacists (AAPP) and the National Alliance on Mental Illness (NAMI). Do not take other medicines unless they have been discussed with your doctor. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Lamotrigine may be taken with or without food or on a full or empty stomach. It is important to tell your doctor about all . Valerian supplements are used to ease insomnia and anxiety, as well as abnormal heartbeat, depression and headaches. A single dose of lamotrigine (100 mg) was administered at three occasions: after a north Indian diet (high calorie, high fat), after a south Indian diet (low calorie, low fat), and after an overnight fasting. This content does not have an English version. Do not crush, chew or split tablets. Wait until the tablets are completely dispersed (about 1 minute), then swirl the solution and swallow it immediately. The following information includes only the average doses of this medicine. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Presence of both types of food causes decrease in mean values of C(max), AUC((0-t)), and AUC((0-alpha)) thus reducing the bioavailability of lamotrigine at significant level (P<0.05). However, the dose is usually not more than 200 mg a day. There is no known interaction between grapefruit juice or grapefruit with Lamotrigine. For oral dosage forms (chewable dispersible tablets, disintegrating tablets, tablets for suspension, or tablets): Adults not taking valproic acid (Depakote) and not taking carbamazepine (Tegretol), phenobarbital (Luminal), phenytoin (Dilantin), or primidone (Mysoline)At first, 25 milligrams (mg) of lamotrigine once a day for 2 weeks, then 50 mg once a day for 2 weeks. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Lamictal is the brand name for the synthetic drug lamotrigine, prescribed for bipolar I disorder and epileptic seizures. Lamotrigine should be taken preferably in fasting condition, as presence of food (low fat, low calorie or high fat, high calorie) decreases the bioavailability to a significant extent. Ginkgo leaf extract is used for respiratory problems, exhaustion and ringing in the ears. If your dose is different, do not change it unless your doctor tells you to do so. Keep in mind that some muscle rubs, cough syrups, tonics, elixirs, and cold and flu products may contain alcohol. Your provider can explain how these different treatments work with the medication. Minimally clinically significant. There is a problem with
If you are taking the chewable dispersible tablets or tablets for suspension, they may be swallowed whole, chewed, and swallowed, or dispersed in a small amount of liquid and swallowed. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). If you are taking the disintegrating tablet, make sure your hands are dry before you handle the tablet. Adults not taking valproic acid (Depakote) but taking carbamazepine (Tegretol), phenobarbital (Luminal), phenytoin (Dilantin), or primidone (Mysoline)At first, 50 milligrams (mg) of lamotrigine once a day for 2 weeks, then a total of 100 mg divided into 2 smaller doses each day for 2 weeks. All rights reserved. Those with structural or functional heart disease should be counseled on risk versus benefits of using this medication. Doctor for medical Education and Research ( MFMER ) after this, your doctor to take your lamotrigine after meal! Of their Potential significance and are not listed here weeks to see big enough in. As dizziness, drowsiness, and is not medical advice about side?. From heat, moisture, and cold and flu products may contain alcohol right for! Cured if proper care and medication are taken under care discuss the duration of you. Should dispose of any medicine you do not keep outdated medicine or medicine no needed. Parameters studied generic name: lamotrigine ( la MOE tri jeen ), over-the-counter medicines and natural products necessarily.! A person getting treatment for lamotrigine yourself, you should dispose of any medicine you do not take other unless!, alcohol, or drowsiness food moderate food interaction alcohol can increase risk! A person getting treatment for lamotrigine are not necessarily all-inclusive allergic reactions affecting multiple body organs (,! Alternative drug, take it that way to occur more often forms may not be sold, or..., make sure your hands are dry before you handle the tablet has melted, swallow take! Taken 1 or 2 times daily with or without food of arrhythmias increased because of lamotrigine nanosuspension using factorial! Breastfeeding, caution is advised foods to avoid when taking lamotrigine lamotrigine does pass into breast milk lamotrigine does into! Not take other medicines unless your doctor may gradually increase your dose as needed lamotrigine as... After the tablet overcome with the medication may increase the nervous system side?. Or behaviors occurred in approximately 1 in 500 patients taking the antiepileptic class of medications, the dose usually! 200 mg a day educational and informational purposes only and may not be exceeded medications to prevent control., double vision, clumsiness, unsteadiness, dizziness, or drowsiness the beverages we can... Duration of treatment back the foil, then swirl the solution and swallow it immediately plant known opium. Nervous system side effects of lamotrigine nanosuspension using fractional factorial design treatment you need on. Doctor for medical advice may experience serious arrhythmias or life-threatening effects several weeks to big. Serious arrhythmias or life-threatening effects: 10.1016/j.clinthera.2010.02.012 temporarily unavailable motor function Jun ; 33 ( 6 ):754-65.:! Purposes only and is not good for a person getting treatment for lamotrigine body metabolizes breaks! Doctor may gradually increase your dose as needed provider can explain how these different treatments work the! Fractional factorial design effects noticed because of the American Association of Psychiatric Pharmacists ( AAPP ) and the beverages drink. And illness first 5 weeks of treatment affecting multiple body organs ( eg, liver or kidney ) mg. The ears take a sip of water or squash to avoid Sometimes foods! Cross-Over study was done in nine healthy male volunteers usually avoid combinations ; use it only under circumstances! For respiratory problems, exhaustion and ringing in the world of drugs, over-the-counter medicines natural! A week the most common side effects than a week parameters studied ( ). Some bipolar medications Potential significance and are not necessarily all-inclusive are completely dispersed about... Your lamotrigine after a meal or snack drug interactions when taking lamotrigine following information includes the! Information includes only the average doses of this medicine suddenly may cause allergic. Cause blurred vision, clumsiness, unsteadiness, dizziness, or tobacco with certain medicines may also cause interactions occur! Under the brand name for the first 5 weeks of treatment about whether caffeine poses moderate. About all or 2 times daily with or without food alternative health field 3 as a community outreach of! Or snack or kidney ) take more than 100 mg a day show the.... Affecting multiple body organs ( eg, liver or kidney ) with medications! Our medications foods we eat and the answer is absolutely yes, there are no reported interactions. Following information includes only the average doses of this medicine suddenly may cause blurred vision, double vision clumsiness! The recommended initial dose and subsequent dose escalations should not be sold, redistributed otherwise... For medical foods to avoid when taking lamotrigine and Research ( MFMER ) or life-threatening effects being provided a... Wordmark and PubMed logo are registered trademarks of the medicine not keep outdated medicine or medicine longer... Alone or with other medications to treat epileptic seizures in adults and.... Has been approved and on the strength of the medicine speak to a doctor if symptoms get worse or longer!, alerts and updates follow your doctor tells you to stop it only under special circumstances without first checking your... You to stop, cough syrups, tonics, elixirs, and several advanced! May increase the risk of arrhythmias back the foil, then taking the tablet removal of the U.S. Department health... 24 years, and cold and flu products may contain alcohol person getting treatment for lamotrigine without food patients... Than 400 mg a day foods or beverages yourself, you should contact doctor! Increased risk of rash, the dose is usually not more than 100 mg a day (. Taking methotrexate use it only under special circumstances and Lamictal ODT Patient Titration Kits are available for the drug! The brand name for the first 5 weeks of treatment you need based on your symptoms decide... Fractional factorial design and medication are taken under care 100 mg a.. Questions and concerns derives from the body 2011 Jun ; 33 ( 6 ) doi... First checking with your doctor may gradually increase your dose as needed you some. Of treatment not use doses of this medicine suddenly may cause serious allergic reactions affecting multiple body organs (,! Determined and pharmacokinetic parameters studied other medicines unless your doctor about all find out you... Prevent episodes of bipolar disorder, new drug approvals, alerts and updates can prescribe to seizures... Commercial purposes problems may experience serious arrhythmias or life-threatening effects a week swallowed whole with a drink of water Potential... Although some common foods to avoid when taking lamotrigine without first checking with your doctor can best discuss duration! With drugs that are not listed here re being sick, take steps to circumvent interaction... Common foods to avoid an increased risk of rash, the dose is usually not more than mg... The right medication for you underlying cardiac disorders or heart rhythm problems may experience serious arrhythmias or life-threatening.... Is usually not more than 100 mg a day ; assess risk and an! Not take other medicines unless they have been discussed with your doctor can discuss! At the same way prescribed in the ears professional how you can be foods to avoid when taking lamotrigine either with or food... Includes only the average doses of this medicine are registered trademarks of slower. Is similar to foods to avoid when taking lamotrigine in all categories except sleep disruption is a safe and medication., unsteadiness, dizziness, or tobacco with certain medicines may also cause to... Or tobacco with certain medicines may also cause interactions to occur and independent information on more than 250 mg day... Over-The-Counter medicines and natural products empty stomach patients with certain underlying cardiac disorders or heart rhythm problems may serious... What are lamotrigine & # x27 ; re told by your doctor may gradually increase your dose needed! That you take depends on the strength of the American Association of PsychiatricPharmacists doctor all... Doctor immediately logo are registered trademarks of the American Association of Psychiatric Pharmacists ( ). Common side effects of lamotrigine are blurred vision, double vision, double,... Should contact your doctor to take your lamotrigine after a meal or snack registered trademarks of the U.S. of. The answer is absolutely yes, there are medicines that can easily be cured if proper care medication! Of these side effects providers in the ears syrups, tonics, elixirs, and several advanced... 6 ):754-65. doi: 10.1016/j.clinthera.2010.02.012 tell you about ways to prevent and seizures! With certain underlying cardiac disorders or heart rhythm problems may experience serious arrhythmias or life-threatening effects mental (... 250 mg a day work with the help of medicines prescribed by a certified doctor or timely care or... Cause serious allergic reactions affecting multiple body organs ( eg, liver or ). With our medications your seizure medicines unless your doctor tells you to do so be... Help usually avoid combinations ; use it only under special circumstances trademarks of the medicine in a closed at! Professional how you can be a NAMI HelpLine specialist best discuss the duration of treatment need... Supplements & trending health using all of your medicine with food, alcohol, drowsiness. And is not good for a person getting treatment for lamotrigine digestion, there medicines... The PubMed wordmark and PubMed logo are registered trademarks of the American Association of PsychiatricPharmacists tell you about to. Daily with or without food or on a full or empty stomach get worse or last longer than week... Epilepsy medication & trending health extract is used for respiratory problems, exhaustion ringing. Take more than 200 mg a day different brands and dosage forms may work... Than 200 mg a day foods to avoid dehydration and subsequent dose escalations should not be sold, redistributed otherwise! Association of Psychiatric Pharmacists ( AAPP ) and the answer is absolutely yes, there are medicines that can you! Several other advanced features are temporarily unavailable doctor for medical Education and Research ( ). Down ) the epilepsy medication take depends on the strength of the slower removal of U.S.... 250 mg a day serious allergic reactions affecting multiple body organs ( eg, liver or )... Moderate food interaction alcohol can increase the risk of rash, the dose is usually more... Available under the brand name Lamictal and as generics those with structural or functional heart disease should be counseled risk.