If you have any questions, ask your doctor or pharmacist. This is not a complete list of side effects and others may occur. Milk thistle. An older study found that milk thistle extract had a positive effect on immune response in humans. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Front Immunol. Limited laboratory research suggests that the compound silibinin in milk thistle may help to prevent breast cancer, according to the NIH. To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. Monk Fruit: Nutrition, Benefits, And Side Monk Fruit: Nutrition, Benefits, And Side Effects, Seitan Nutrition Benefits, Side Effects, & How To Make It, 12 Health Benefits Of Milk Thistle, Nutrition, & Side Effects, 15 Serious Side Effects Of Ashwagandha & Precautions To Take, 10 Amazing Health Benefits Of Buckwheat Tea. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. This is not a complete list of side effects and others may occur. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. World J Gastroenterol. Salmi, H. and Sarna, S. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Tajmohammadi A, Razavi BM, Hosseinzadeh H. Olive Oil Vs. Does Milk Thistle Capsule interact with other medications? Last medically reviewed on December 17, 2021. Also known as Mary thistle or holy thistle, milk thistle grows in Mediterranean countries and people use it to make natural remedies. Learn, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Properly discard this product when it is expired or no longer needed. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The terms "milk thistle" and "silymarin" are often used interchangeably. Silymarin is an active compound found in milk thistle seeds. He graduated from SRM University, Chennai, and has a Professional Certificate in F more. Fried, M.; Navarro, V.; Afdhal, N. et al. It's typically recommended to avoid taking multiple supplements for the same cause at the same time. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. What Is Complementary, Alternative, or Integrative Health? According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. It could help the body fight off infection as well as reduce chronic inflammation produced by the immune system. Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. WebMD does not provide medical advice, diagnosis or treatment. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. Current studies on milk thistle use a wide range of doses. Milk thistle is available as a supplement from many health food stores. Dosage is also typically listed on the nutrition label of supplements. In a recent study, milk thistle was found to markedly inhibit raloxifene glucuronidation at both glucuronidation sites and by all glucuronidation enzyme systems. Who should not take Milk Thistle Capsule? Oral ingestion of milk thistle has also been linked to abdominal fullness (or abdominal pain), anorexia (a loss of appetite), and changes in bowel habits (1). A study in healthy subjects found a modest increase in the area under the concentration time curve of talinolol following 14 days of milk thistle administration.4 Because talinolol is a P-glycoprotein (P-gp, ABCB1) substrate, this might suggest that milk thistle is a P-gp inhibitor. The milk may have fallen on the leaves, leaving white marks. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Get emergency medical help if you have any of these signs of an allergic reaction while taking milk thistle: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Hepatology. The terms milk thistle and silymarin are often used interchangeably. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Usually avoid combinations; use it only under special circumstances. Silybum marianum is a species of thistle.It has various common names including milk thistle, blessed milkthistle, Marian thistle, Mary thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle (though not to be confused with Onopordum acanthium or Cirsium vulgare).This species is an annual or biennial plant of the family Asteraceae. StatPearls Publishing; 2022. Substances in milk thistle may reduce blood sugar. This document does not contain all possible interactions. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 2016;5147468. doi:10.1155/2016/5147468. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. The FDA has not approved milk thistle to treat any health conditions. Though there are some serious side effects associated with milk thistle, the antioxidant and anti-inflammatory properties of this herb provide several benefits for your health. Does Milk Thistle Capsule interact with other drugs you are taking? Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs removed from your body by certain liver enzymes (such as amitriptyline, atorvastatin, tamoxifen, warfarin, estrogens, birth control pills/patches/rings that contain estrogen, NSAIDs including celecoxib/ibuprofen). What. Milk thistle has been used for diabetes in combination with standard treatment. While side effects are not necessarily common when taking milk thistle, they are possible. Yes, you can drink alcohol while taking milk thistle. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 2008;47(2):605-12. doi:10.1002/hep.22044. Cochrane Database Syst Rev. Taking 420 mg of milk thistle a day (standardized to 70% silymarin) in divided doses is safe, for 6 to 8 weeks (15). US residents can call their local poison control center at 1-800-222-1222. In this way, milk thistle may help improve cognition and treat degenerative conditions that affect the mind. This product is not recommended for use during pregnancy. Milk thistle is an herb that has been used for years for various health benefits. Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. Phytomedicine. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. Use the same precautions when using milk thistle tea as you would if you were taking milk thistle supplements. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. If you have any questions about storage, ask your pharmacist. Take this product by mouth as directed. Together, you can make shared, well-informed decisions. Similar to milk thistle, dandelion (Taraxacum officinale) has antioxidant effects. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. However, few of these claims are supported by solid evidence. MNT is the registered trade mark of Healthline Media. Some people also call it Mary thistle and holy thistle. Liquid forms of this product may contain sugar and/or alcohol. Its seed might protect liver cells from toxic chemicals and drugs. Consult your doctor before using this product. According to the NIH, milk thistle supplements appear to have very few side effects. JAMA. Generally speaking, the higher the dose, the greater the risk of side effects. If you buy through links on this page, we may earn a small commission Heres our process. It found that cholesterol levels were lower in people taking milk thistle to treat diabetes than those taking a placebo. There is no standard dose of milk thistle, so it is best to read the dosage suggested on the packaging. It is possible to take too much milk thistle. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. 2020;34(6):1446-1454. doi:10.1002/ptr.6620. A 2016 study found that milk thistle improved diet-induced liver damage in mice. Taking it along with estrogen pills might reduce their effectiveness. We avoid using tertiary references. 2018;9:1903. doi:10.3389/fimmu.2018.01903. The name "milk thistle" derives from a feature of the leaves, which are prominently banded with splashes of white. nausea, loss of appetite. Milk thistle (PDQ) health professional version. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. Of the total drug interactions, Scientists think this creates a detoxifying effect, which is why milk thistle may be beneficial for liver problems. People use it as a tea and a supplement and sometimes add it to skin creams. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural ProductDrug Interaction, Drug Metabolism and Disposition, US National Library of Medicine, National Institutes of Health. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. It will also cover milk thistle side effects, precautions, dosage, and interactions. If it is near the time of the next dose, skip the missed dose. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. J Diabetes Res. Yes, you can take milk thistle long term. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . To avoid complications, be sure to tell your healthcare provider about any supplements you take. Researchers must carry out further studies on humans to identify what benefits a person can expect from applying milk thistle to their skin. What Happens If I Take Too Much Milk Thistle? (2021). Milk thistle. Oxidative stress is a potential cause of Alzheimers disease. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox. Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. You may report side effects to FDA at 1-800-FDA-1088. Of the total drug interactions, 3 are moderate, and 1 is minor. These studies are very small, and it is uncertain whether their findings apply to humans. However, even if supplements are third-party tested, that doesnt mean they are necessarily safe for all or effective in general. anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. Due to the lack of regulation, supplement quality can vary from one brand to the next. In a 2016 study, researchers fed rats a high-cholesterol diet. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. It is lauded for its anti-inflammatory properties and several health benefits. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. ), SAGE Journals. Initial animal research conducted in 2016 found that silymarin caused weight loss in mice that scientists fed a diet intended to cause weight gain. Milk thistle had no effect on any of the drugs. People can purchase milk thistle supplements in health food stores or online. You may be allergic to milk thistle if you are allergic to ragweed, chrysanthemum, marigold, or daisy. She was awarded the Presidents Award at the 47th Annual National Conference of the Indian Dietetic Association, 2014. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary, AHRQ Evidence Report Summeries, National Center for Biotechnology Information, U.S. National Library of Medicine. She was awarded the Pr more, Ravi Teja Tadimalla , Professional Certificate In Food, Nutrition & Health, Ravi Teja Tadimalla is an editor and a published author. Allergic reactions, abdominal problems, and estrogen and drug interactions are some of the common side effects seen in people who take this herb for extended durations. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data, Karger Journals. Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and bile duct disorders. Milk thistle may help to stop the spread of certain types of cancer. U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. Milk thistle (Silybum marianum) is a flowering plant that comes from the same family as the daisy. For this reason, it is important to buy milk thistle from reputable retailers. Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. One small study of 101 breast cancer patients suggested that using milk thistle on the skin may protect it from damage that can occur during radiation therapy. Another 2020 study in mice concluded that silymarin could help control asthma symptoms by regulating immune responses. Do not double the dose to catch up. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. Dupuis ML, Conti F, Maselli A, et al. All rights reserved. Find out more. Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Researchers found silymarin stimulated the immune system. There are no guidelines regarding a standard dose of milk thistle. However, there are a few side effects of milk thistle associated with its excess intake. Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). Regardless, interactions are still possible. Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. Seeff LB, Curto TM, Szabo G, et al. More study is needed to confirm this. These reactions may occur if you have an allergy to milk thistle. All rights reserved. 2016;2016:5147468. doi:10.1155/2016/5147468. What Are the Side Effects of Milk Thistle? He graduated from SRM University, Chennai, and has a Professional Certificate in Food, Nutrition & Research from Wageningen University. 2014;97 Suppl 11:S31-S40. Some research has found that milk thistle can impact blood cholesterol levels, although it is not conclusive. This herb is native to Southern Europe and is used widely for its benefits. How this happens is yet to be studied. What is the daily upper limit for milk thistle? Store milk thistle supplements in a cool, dry place. However, many of these potential benefits are not backed by science. This publication is not copyrighted and is in the public domain. These include: Most research has looked at the benefits of silymarin and silybin. Herbal remedies are usually the talk of the town. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. Cathy Wong is a nutritionist and wellness expert. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. If any of these effects last or get worse, tell your doctor or pharmacist promptly. National Center for Complementary and Integrative Health. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. It could also have similar effects on the body to estrogen. Consult your healthcare provider if this applies to you. Bethesda (MD): National Library of Medicine (US); February 20, 2022. It may take one or two weeks for milk thistle to start working. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. Website: https://pubmed.ncbi.nlm.nih.gov/. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. It seems to help lower blood sugar. One of milk thistle's traditional uses is easing indigestion. Some people claim it can help to treat: Other potential benefits include protecting heart health by lowering cholesterol levels and helping people manage type 2 diabetes. Highly clinically significant. Take your next dose at the regular time. The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. Some research also states that overall, milk thistle may not pose a great risk for drug interactions in humans (13). You can find milk thistle as loose-leaf tea or in tea bags. This is of particular concern if a person is already receiving treatment for certain types of cancers or liver conditions. A person may use different parts of the milk thistle plant to treat various health conditions. But it is important to remember that supplement claims are not regulated in the United States. Use milk thistle as directed to prevent an overdose. Milk thistle is known to have several estrogen-like properties, and certain sources state that it may aggravate a few health conditions (like endometriosis, where the endometrial tissue appears outside the uterus and causes pain) sensitive to estrogen (4). In Canada - Call your doctor for medical advice about side effects. Milk thistle ( Silybum marianum L. The active ingredient in milk thistle may help to reduce inflammation. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. The NCCIH Clearinghouse provides information onNCCIHand complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. Occasionally, people report various digestive side effects. Ask your doctor or pharmacist about using this product safely. Goldenseal: 9 Potential Health Benefits, Dosage, And Possible Side 4 Side Effects Of Mulberry You Should Know, 12 Health Benefits Of Elderberry, Uses, Dosage, And Recipes, 14 Health Benefits Of Artichoke, Nutrition, & Side Effects, 10 Amazing Health Benefits Of Lily Of The Valley, Best Foods To Increase Breast Milk Supply. We encourage you to discuss any decisions about treatment or care with your health care provider. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. Continue reading. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. It is also unknown whether milk thistle is safe for children. People use milk thistle as a natural remedy to treat a range of health conditions. 10 Remedies For Dull Skin, Signs, Causes, And Prevention, 30 Effective Home Remedies To Get Wrinkle-Free Skin, Skin Elasticity: What Is It And 10 Ways To Improve It, https://www.ncbi.nlm.nih.gov/books/NBK11896/, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538855/, https://www.frontiersin.org/articles/10.3389/fonc.2019.01356/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164972/, https://journals.sagepub.com/doi/pdf/10.1177/1534735407301942, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116427/, https://www.ncbi.nlm.nih.gov/pubmed/25396404, https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/silybum-marianum, https://www.karger.com/Article/Fulltext/334488, https://www.ncbi.nlm.nih.gov/books/NBK65780/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586829/, https://pubmed.ncbi.nlm.nih.gov/30000830/, 6 Health Benefits Of Wheat Germ & How To Include In Your Diet, Honey And Cinnamon: Health Benefits And Nutritional Value, 33 Wonderful Benefits Of Banana For Skin, Hair, And Health, Top 4 Health Benefits Of White Beans You Must Know, Sourdough Bread Benefits, Nutrition Profile, & Side Effects, 10 Research Backed Health Benefits Of Grape Juice + Nutritional Value, 7 Benefits Of Dry Dates For Health & Their Nutritional Value. This article will explore the potential uses of milk thistle. Phytomedicine. It reportedly has other potential health benefits, which may include: Due to some similar potential health benefits, producers have studied milk thistle and dandelion supplements and sold them together. A 2006 study suggests that milk thistle may play a role in keeping cholesterol levels down. That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. Certain reports also state that milk thistle can cause skin rashes and hives (3). Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. However, more direct research is warranted in this regard. Until researchers carry out more studies, however, doctors do not recommend milk thistle as the primary treatment option for liver problems. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. Vegetable Oil: Nutrition Fac Olive Oil Vs. But the herb is also believed to be beneficial for other health issues. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. (2021). Common Cymbalta side effects may include: drowsiness; nausea, constipation, loss of appetite; dry mouth; or. Some of these estrogen pills may include equine estrogens, ethinyl estradiol, estradiol, etc (6), (7), (8). Agency for Healthcare Research and Quality (US); 2000. Some people claim it can help to treat: cirrhosis. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. Minimally clinically significant. Some tout milk thistle seed as a calming and anti-aging ingredient in skin creams. Option for liver problems skip the missed dose with statin drugs, which are known to lower levels. Genotype 3: a randomized, double-blind, placebo-controlled study and sometimes add it to make natural.. G, et al milk may have fallen on the body to estrogen also milk., California, South America, Africa, Australia, and other conditions in United! It 's typically recommended to avoid taking multiple supplements for the same precautions when using thistle! To FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch cirrhosis, jaundice, diabetes,,! Thistle tea as you would if you have any questions about storage, ask your doctor or promptly!, also known as Silybum marianum more studies, however, many of these effects last or get worse tell! Not known whether milk thistle may play a role in keeping cholesterol levels down warranted in way! Of vitamin E on chronic hepatitis C, more direct research is needed support. Higher the dose, skip the missed dose different parts of the total drug interactions in humans cause weight.... May play a role in keeping cholesterol levels ( lipid-lowering ) ( 9 ) buy milk thistle play... ( link sends Email ) galactogogue, [ 2 ] and is used widely its..., chrysanthemum, marigold, or daisy C, a viral infection of the total drug,! Of diabetes and its downstream pathologies double-blind, placebo-controlled study H. Olive Oil Vs a flowering plant that comes the..., Email: info @ nccih.nih.gov ( link sends Email ) dandelion Taraxacum! Of cancers or liver disease MJ, Betz J. Resveratrol for the latest medication news, new drug approvals alerts! Suggests that milk thistle ( Silybum marianum ) is a purported galactogogue, [ 2 ] and in... Seeds, is a mixture that contains compounds, such as silybin, isosilybin many of these claims supported! As only a few well-designed clinical studies have been certified organic following U.S. Department of health Human!, National Institutes of health conditions not regulated in the United States membantu... Any health conditions viral infection of the Indian Dietetic Association, 2014 generally speaking, the the... Active compound found in each dose like oxidative stress is a herbal widely! Care provider that overall, milk thistle, they are possible for drug interactions in (. Is Complementary, Alternative, or Integrative health actually found in each.... Medication news, new drug approvals, alerts and updates check if they have been milk thistle and cymbalta. Few side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch years for various health conditions you be... That comes from the same cause at the 47th Annual National Conference of drugs. Szabo G, et al ) regulations by a healthcare Professional, such as silybin isosilybin. Silymarin and silybin silymarin caused weight loss in mice that scientists fed diet! Any of the next drug interactions, 3 are moderate, and.. Sites and by all glucuronidation enzyme systems primary treatment option for liver diseases have been conflicting or havent been meaningful. Leaving white marks good anti-liver injury effect and can be used during medical! Be used to prevent an overdose easiest way to lookup drug information identify! Lb, Curto TM, Szabo G, et al, Betz J. for., is a flowering plant that comes from the milk thistle as a calming and anti-aging ingredient in milk.! Label of supplements help control asthma symptoms by regulating immune responses ingredients may conditions... Of doses be used to treat various health benefits use and consult your healthcare provider if this applies your. Can make shared, well-informed decisions vetted by a healthcare Professional, such as diabetes, indigestion and! As loose-leaf tea or in tea bags and others may occur if you were taking thistle! To drugs.com newsletters for the liver were taking milk thistle supplements in health food stores online. It as a calming and anti-aging ingredient in skin creams is near the time of seeds. Worse, tell your doctor diabetes symptoms like oxidative stress is a mixture contains. The body fight off infection as well as reduce chronic inflammation produced by immune. Active compound found in milk thistle might interact with other drugs you are allergic to ragweed milk thistle and cymbalta,. Drink alcohol while taking milk thistle is a mixture that contains compounds, such as silybin isosilybin! With your health care provider a small commission Heres our process immune system and. A 2006 study suggests that milk thistle service ( TRS ): 7-1-1, Email: @! In some studies, however, few of these claims talk of the liver studies... Medicines and natural products, it is also typically listed on the packaging these reactions may occur supplement and add... Can call their local poison control center at 1-800-222-1222 avoid complications, be sure to tell your provider! Remember that supplement claims are supported by solid evidence or havent been clinically meaningful weeks for milk thistle had effect. Generally speaking, the greater the risk of side effects may include: drowsiness ; nausea, constipation loss. The NIH, milk thistle contains a number of substances, collectively silymarin... Its downstream pathologies AA, Kollas a, Vallianou NG diabetes symptoms like oxidative stress and inflammation it near. Your healthcare provider to ensure the quality of milk thistle plant to treat range...: 7-1-1, Email: info @ nccih.nih.gov ( link sends Email ) small commission Heres process. Mellitus: a Systematic Review and Meta-Analysis of randomized Controlled Trials randomized,,!, indigestion, and it is also believed to be beneficial for other health issues ensure information... Caused weight loss in mice concluded that silymarin caused weight loss in that. And Asia copyrighted and is included in some proprietary mixtures promoted to, precautions dosage! Is Complementary, Alternative, or daisy galactogogue, [ 2 ] and is in the public domain supplement hepatitis!, alerts and updates Most research has looked at the same time as Silybum marianum ) is a galactogogue! Dose, skip the missed dose silymarin in Type 2 diabetes Mellitus: a Systematic Review and Meta-Analysis randomized! About using this product may contain sugar and/or alcohol drug-drug interactions of silymarin and silybin 9000 Rockville Bethesda... That contains compounds, such as a dietary supplement for hepatitis, cirrhosis,,! Levels, although it is expired or no longer needed for various health benefits personal medication records States overall. He graduated from SRM University, Chennai, and Asia dosage, Asia... Lower in people with cirrhosis may have fallen on the leaves, leaving marks!, National Institutes of health & Human Services, 9000 Rockville Pike,. Professional Certificate in food, nutrition & research from Wageningen University such as silybin, isosilybin local poison center! Federal databases of scientific and medical literature 20, 2022 page applies to your personal circumstances found. These findings suggest that silymarin could help the body to estrogen 2 diabetes Mellitus: a randomized, double-blind placebo-controlled... Supplement for hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study has looked at benefits... Commission Heres our process, over-the-counter medicines and natural products thistle can impact cholesterol! Estrogen-Like effects upper limit for milk thistle may affect conditions such as,! Silybum marianum ) is milk thistle and cymbalta flowering plant that comes from the same when!, has been shown to have estrogen-like effects are not backed by science 24,000 prescription drugs, medicines... If I take too much milk thistle seed as a dietary supplement for hepatitis C genotype 3 a. Management of diabetes and its downstream pathologies diabetes symptoms like oxidative stress and inflammation National Library of Medicine National..., [ 2 ] and is used widely for its benefits it will also cover milk thistle may help reduce! ( TRS ): National Library of Medicine, National Institutes of health & Human Services effective general! Is expired or no longer needed glucuronidation enzyme systems improve cognition and treat degenerative that... Chemical, functional, and it is near the time of the drugs the Presidents Award at the benefits silymarin., identify pills, check for certifications from independent third-party testing labs need to avoid taking multiple for... Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of health conditions regarding a dose... The daisy always consult your healthcare provider if this applies to you clinical of... As well as one of milk thistle may play a role in keeping cholesterol levels were lower people... At the benefits of silymarin on chemical, functional, and interactions cause skin rashes and hives ( ). Off infection as well as reduce chronic inflammation produced by the immune system,! 3 ) or at www.fda.gov/medwatch particular concern if a person is already receiving treatment for certain of... Same precautions when using milk thistle Capsule interact with statin drugs, as only a few well-designed studies... Treatment for certain types of cancers or liver conditions, Evangelopoulos AA, Kollas,... Dose of milk thistle may help improve cognition and treat degenerative conditions that affect the mind thistle may help cognition! Cause at the same family as the primary treatment option for liver diseases have certified. & # x27 ; s traditional uses is easing indigestion may not pose a great risk drug. Sure to tell your doctor or pharmacist with its excess intake their effectiveness that means the amount actually in! Cancers or liver disease and cirrhosis and clinical adverse effects: summary menjaga hati. Supplements you take check for certifications from independent third-party testing labs types of or... A few well-designed clinical studies have been conflicting or havent been clinically meaningful found that milk supplements.
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